R is a hugely popular language among data scientists and statisticians. One of the difficulties with open-source R is the memory constraint. All the data needs to be loaded into a data.frame. Microsoft solves this problem with the RevoScaleR package of the Microsoft R Server. Just launched this week is an EdX course on
Analyzing Big Data with Microsoft R Server.

According the syllabus:

Upon completion, you will know how to use R for big-data problems.

Full Disclosure: I work at Microsoft, and the course instructor, Seth Mottaghinejad, is one of my colleagues.